The open index of psychedelic research

The median effective dose (ED<sub>50</sub>) of remimazolam combined with esketamine for conscious sedation in patients with dental anxiety undergoing outpatient dental surgery: a prospective, dose-finding study.

Che M, Kang C, Zhou C +7

Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.

Seo Y

Beyond Enthusiasm: Ayahuasca and the Future of Depression Research.

Sá Filho AS, Fajemiroye JO, Nardi AE +1

Who are you, ketamine? Good, evil, or dose- and context-dependent?

Galdino de Oliveira E

Caution in interpreting value-related change after psilocybin: Comment on Kerr-Gaffney et al. (2026).

Tahamtan G, Chernoloz O

Toward a nuanced framework for the medical development of ibogaine and its analogues and derivatives: implications for psychopharmacology.

Verrico CD, Averill LA, Moore CJ +3

The need for another tool: Australian healthcare professionals on the use of psilocybin for existential distress in people with cancer.

Adler H, Filipic R, Gonzalez M +8

MDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.

Morley KC, Arunogiri S, Mills K +8

Esketamine-augmented stellate ganglion block improves postoperative sleep quality after gynecological laparoscopic surgery: a randomized controlled trial.

Wang YL, Zhou L, Xu R +4

Psilocybin as a Treatment for Chronic Pain in Smokers

Effectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study.

Glozier N, Morris R, Stratton E +21

Psilocibin: Current Evidence, Safety Signals, and Challenges in Assessing Potential Multi-Organ Effects.

Buczma K, Kamińska K, Kasarełło K +4

Policy pathways and historical insights: Canada's evolving approach to psychedelic access for end-of-life distress.

Kratina S, Schwartz R, Strike C +2

Disrupted self-referential processing and empathy-based interventions in mental disorders: neural mechanisms, cognitive biases, and therapeutic integration.

Siqintu, Bao Q, Yang D +8

Catecholamine modulation of frontal cortical ignition during wakefulness, sleep and anesthesia.

Li B, Zhao J, Dan Y

Psychedelic-Assisted Treatments for Canadian Military Personnel and Veterans: Scoping Review and Environmental Scan Protocol

Open MDMA: An Evidence-Based Synthesis, Theory, and Manual for MDMA Therapy Based on Memory Reconsolidation, Complex Systems, and the Defense Cascade

Groeneveld M

Descriptive Patterns of Ketamine Administration Among Adult Emergency Department Patients at a Single Academic Center in Saudi Arabia.

Aljadeed R, Aljadeed R, Kalagi N +2

Physicochemical Stability of an S-Ketamine-Dexmedetomidine Anesthetic Mixture: An In Vitro Study.

Zuazo S, Santiago B

Theorizing ahead of the data: A commentary on Piper et al.

Noël X

Single Ayahuasca administration attenuates alcohol relapse and associated behavioral, neurochemical, and oxidative alterations in rats.

Lodetti G, de Bitencourt RM, Inserra A +14

Pupil-DLC: An open-source deep learning pipeline for scalable, marker-less tracking of pupil dynamics across conscious and unconscious states.

Seyfourian P, Marks LC, Claar LD +4

High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Shah K, Herzog R, Swann AC +4

Esketamine Versus Erector Spinae Plane Block in Video-assisted Thoracoscopic Surgery: A Comments.

Zaheer I, Saqib M, Yousaf M +1