Carhart-Harris RL

Carhart-Harris Lab, Departments of Neurology, Psychiatry and Behavioral Sciences, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA.

94 papers · 23 preprints · ORCID

ArticlePsilocybin

The entropic brain today.

Carhart-Harris RL

Europe PMC2026
ArticlePsychedelics

Psychedelics Trials and Outcomes-A Closer Look.

Carhart-Harris RL, Rosenblat JD

Europe PMC2026
ArticlePsilocybin

On the meaning of "plasticity" in neuroscience and mental health research and its relation to the action of psychedelic therapy.

Carhart-Harris RL, Zeifman RJ, Pasquini L +8

Europe PMC2026
ArticlePsilocybin

Psychedelics align brain activity with context.

Stoliker D, Novelli L, Khajehnejad M +16

Europe PMC2026
ArticlePsilocybin

Psilocybin therapy for adult females with anorexia nervosa: pilot study.

Douglass HM, Spriggs MJ, Godfrey K +17

Europe PMC2026
ArticlePsilocybin

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Pasquini L, Vohryzek J, Escrichs A +12

Europe PMC2026
PreprintPsilocybin

Divergent changes in perturbation-induced brain reconfiguration following depression treatment with psilocybin and escitalopram

Dagnino PC, Acero-Pousa I, Carhart-Harris RL +5

Europe PMC2026
PreprintPsilocybin

Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem

Dagnino PC, Acero-Pousa I, Zamora-López G +7

Europe PMC2026
ArticleIbogaine

Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series.

Tabaac BJ, Carhart-Harris RL, Yung T

Europe PMC2026
ArticlePsilocybin

Human brain changes after first psilocybin use.

Lyons T, Spriggs M, Kerkelä L +20

Europe PMC2026
ArticlePsilocybin

An international mega-analysis of psychedelic drug effects on brain circuit function.

Girn M, Doss MK, Roseman L +24

Europe PMC2026
ArticlePsychedelics

The science of psychedelic medicine.

Siegel JS, Liston C, Nicol GE +2

Europe PMC2026
ArticlePsychedelics

Blunted Psychedelic Drug Effects in Older Adults.

Aday JS, Carhart-Harris RL, Boehnke KF

Europe PMC2026
PreprintPsilocybin

A Mesoscale Framework for Psychedelic Drug Action in the Human Brain

Dai R, Cofre R, Timmermann C +4

Europe PMC2025
ArticleMDMA

Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.

Ertl N, Ashraf I, Azizi L +5

Europe PMC2026
ArticlePsilocybin

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.

Vohryzek J, Luppi AI, Atasoy S +4

Europe PMC2025
ArticlePsychedelics

Exploring the potential psychological predictors associated with changes in depression, anxiety, and well-being following naturalistic psychedelic use.

Herrmann FM, Jones G, Low DM +3

Europe PMC2025
PreprintPsilocybin

Accurate and Interpretable Prediction of Antidepressant Treatment Response from Receptor-informed Neuroimaging

Tolle HM, Luppi AI, Lawn T +4

Europe PMC2025
ArticlePsilocybin

Human neuroimaging: fMRI.

Wall MB, Carhart-Harris RL

Europe PMC2025
ArticlePsilocybin

Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies.

Roseby W, Kettner H, Roseman L +7

Europe PMC2025
ArticlePsilocybin

Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression.

Wall MB, Demetriou L, Giribaldi B +5

Europe PMC2025
ArticlePsychedelics

Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use.

Zhou K, de Wied D, Carhart-Harris RL +1

Europe PMC2025
ArticleDMT

Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.

Timmermann C, Sanders JW, Reydellet D +16

Europe PMC2025
ArticleDMT

Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience.

Singleton SP, Timmermann C, Luppi AI +4

Europe PMC2025
ArticleDMT

Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self.

Pasquini L, Simon AJ, Gallen CL +5

Europe PMC2025
ArticlePsilocybin

Exploring serotonergic psychedelics as a treatment for personality disorders.

Carrithers BM, Roberts DE, Weiss BM +7

Europe PMC2025
ArticlePsychedelics

On Minimizing Risk and Harm in the Use of Psychedelics.

Evans J, Aixalà M, Anderson BT +28

Europe PMC2025
PreprintMDMA

Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects

Ertl N, Ashraf I, Azizi L +5

Europe PMC2025
ArticlePsilocybin

A qualitative analysis of the psychedelic mushroom come-up and come-down.

Brouwer A, Brown JK, Erowid E +4

Europe PMC2025
ArticlePsilocybin

From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).

Zeifman RJ, Spriggs MJ, Kettner H +5

Europe PMC2025
PreprintPsychedelics

Diminished functional gradient of the precuneus during altered states of consciousness

Lyu D, Adapa R, Carhart-Harris RL +5

Europe PMC2024
PreprintPsilocybin

Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

Pasquini L, Vohryzek J, Escrichs A +12

Europe PMC2024
ArticleDMT

Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being.

Bonnelle V, Feilding A, Rosas FE +3

Europe PMC2024
ArticlePsychedelics

Psychotomimetic compensation versus sensitization.

Brouwer A, Carhart-Harris RL, Raison CL

Europe PMC2024
ArticlePsychedelics

Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?

Pasculli G, Busan P, Jackson ES +7

Europe PMC2024
ArticlePsychedelics

Psychological effects of psychedelics in adolescents.

Izmi N, Carhart-Harris RL, Kettner H

Europe PMC2024
PreprintDMT

Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT

Vohryzek J, Luppi A, Atasoy S +4

Europe PMC2024
ArticlePsychedelics

Effects of Psychedelics in Older Adults: A Prospective Cohort Study.

Kettner H, Roseman L, Gazzaley A +2

Europe PMC2024
ArticleAyahuasca

Long-term benefits to psychological health and well-being after ceremonial use of Ayahuasca in Middle Eastern and North African immigrants and refugees.

Lowe MX, Kettner H, Jolly DRP +2

Europe PMC2024
ArticleDMT

The flattening of spacetime hierarchy of the <i>N,N</i>-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.

Vohryzek J, Cabral J, Timmermann C +6

Europe PMC2024
PreprintDMT

Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing

Bonnelle V, Feilding A, Rosas FE +3

Europe PMC2024
ArticlePsychedelics

Psychiatric risks for worsened mental health after psychedelic use.

Marrocu A, Kettner H, Weiss B +3

Europe PMC2024
PreprintPsilocybin

The Temporal Trajectory of the Psychedelic Mushroom Experience Mimics the Narrative Arc of the Hero’s Journey

Brouwer A, Brown JK, Erowid E +4

Europe PMC2024
PreprintDMT

Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

Pasquini L, Simon AJ, Gallen CL +5

Europe PMC2024
ArticlePsilocybin

Brain dynamics predictive of response to psilocybin for treatment-resistant depression.

Vohryzek J, Cabral J, Lord LD +6

Europe PMC2024
ArticleDMT

Effects of DMT on mental health outcomes in healthy volunteers.

Timmermann C, Zeifman RJ, Erritzoe D +2

Europe PMC2024
ArticleLSD

Effects of External Stimulation on Psychedelic State Neurodynamics.

Mediano PAM, Rosas FE, Timmermann C +10

Europe PMC2024
ArticlePsilocybin

Psilocybin and Other Classic Psychedelics in Depression.

Nutt DJ, Peill JM, Weiss B +3

Europe PMC2024
PreprintPsilocybin

Statistical diversity distinguishes global states of consciousness

Starkey J, Carhart-Harris RL, Pigorini A +2

Europe PMC2023
PreprintPsilocybin

The entropic heart: Tracking the psychedelic state via heart rate dynamics

Rosas FE, Mediano PA, Timmermann C +9

Europe PMC2023
ArticleDMT

Psychological and physiological effects of extended DMT.

Luan LX, Eckernäs E, Ashton M +10

Europe PMC2024
ArticleLSD

LSD-induced changes in the functional connectivity of distinct thalamic nuclei.

Delli Pizzi S, Chiacchiaretta P, Sestieri C +10

Europe PMC2023
ArticleMDMA

Case analysis of long-term negative psychological responses to psychedelics.

Bremler R, Katati N, Shergill P +2

Europe PMC2023
ArticlePsilocybin

Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences.

Zeifman RJ, Kettner H, Pagni BA +5

Europe PMC2023
PreprintDMT

Harmonic decomposition of spacetime (HADES) framework characterises the spacetime hierarchy of the DMT brain state

Vohryzek J, Cabral J, Timmermann C +6

Europe PMC2023
ArticlePsilocybin

In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.

Luppi AI, Hansen JY, Adapa R +23

Europe PMC2023
ArticlePsilocybin

Personality change in a trial of psilocybin therapy v. escitalopram treatment for depression.

Weiss B, Ginige I, Shannon L +8

Europe PMC2024
PreprintDMT

Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience

Singleton SP, Timmermann C, Luppi AI +4

Europe PMC2023
ArticlePsilocybin

How does psilocybin therapy work? An exploration of experiential avoidance as a putative mechanism of change.

Zeifman RJ, Wagner AC, Monson CM +1

Europe PMC2023
ArticlePsilocybin

Increased low-frequency brain responses to music after psilocybin therapy for depression.

Wall MB, Lam C, Ertl N +4

Europe PMC2023
ArticleLSD

Spatial Correspondence of LSD-Induced Variations on Brain Functioning at Rest With Serotonin Receptor Expression.

Delli Pizzi S, Chiacchiaretta P, Sestieri C +8

Europe PMC2023
ArticleDMT

Human brain effects of DMT assessed via EEG-fMRI.

Timmermann C, Roseman L, Haridas S +12

Europe PMC2023
ArticlePsychedelics

Translational Challenges in Psychedelic Medicine.

Carhart-Harris RL

Europe PMC2023
ArticleKetamine

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.

Luppi AI, Vohryzek J, Kringelbach ML +16

Europe PMC2023
ArticlePsilocybin

Among psychedelic-experienced users, only past use of psilocybin reliably predicts nature relatedness.

Forstmann M, Kettner HS, Sagioglou C +4

Europe PMC2023
ArticlePsilocybin

Canalization and plasticity in psychopathology.

Carhart-Harris RL, Chandaria S, Erritzoe DE +11

Europe PMC2023
ArticleLSD

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans.

Kanen JW, Luo Q, Rostami Kandroodi M +5

Europe PMC2023
ArticlePsilocybin

Body mass index (BMI) does not predict responses to psilocybin.

Spriggs MJ, Giribaldi B, Lyons T +9

Europe PMC2023
ArticlePsilocybin

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape.

Singleton SP, Luppi AI, Carhart-Harris RL +7

Europe PMC2022
ArticleKetamine

Psychedelics and schizophrenia: Distinct alterations to Bayesian inference.

Rajpal H, Mediano PAM, Rosas FE +7

Europe PMC2022
ArticlePsilocybin

Antidepressant effects of a psychedelic experience in a large prospective naturalistic sample.

Nygart VA, Pommerencke LM, Haijen E +6

Europe PMC2022
PreprintPsilocybin

Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape

Luppi AI, Hansen JY, Adapa R +24

Europe PMC2022
PreprintPsilocybin

Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Vohryzek J, Cabral J, Lord L +6

Europe PMC2022
ArticlePsilocybin

Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses.

McCulloch DE, Knudsen GM, Barrett FS +10

Europe PMC2022
PreprintPsilocybin

Increased low-frequency brain responses to music after psilocybin therapy for depression

Wall MB, Lam C, Ertl N +4

Europe PMC2022
ArticlePsychedelics

Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience.

Peill JM, Trinci KE, Kettner H +6

Europe PMC2022
ArticlePsychedelics

Examining Psychedelic-Induced Changes in Social Functioning and Connectedness in a Naturalistic Online Sample Using the Five-Factor Model of Personality.

Weiss B, Nygart V, Pommerencke LM +2

Europe PMC2021
ArticlePsychedelics

Psychedelics alter metaphysical beliefs.

Timmermann C, Kettner H, Letheby C +3

Europe PMC2021
ArticlePsychedelics

Psychedelic experience dose-dependently modulated by cannabis: results of a prospective online survey.

Kuc J, Kettner H, Rosas F +5

Europe PMC2022
ArticlePsilocybin

Study Protocol for "Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study".

Spriggs MJ, Douglass HM, Park RJ +11

Europe PMC2021
ArticlePsychedelics

Turn on, Tune in, and Drop out: Predictors of Attrition in a Prospective Observational Cohort Study on Psychedelic Use.

Hübner S, Haijen E, Kaelen M +2

Europe PMC2021
ArticlePsilocybin

Sustained, Multifaceted Improvements in Mental Well-Being Following Psychedelic Experiences in a Prospective Opportunity Sample.

Mans K, Kettner H, Erritzoe D +3

Europe PMC2021
ArticlePsilocybin

Psychedelics and health behaviour change.

Teixeira PJ, Johnson MW, Timmermann C +5

Europe PMC2022
PreprintPsilocybin

LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory

Singleton SP, Luppi AI, Carhart-Harris RL +7

Europe PMC2021
ArticlePsychedelics

Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?

Carhart-Harris RL, Wagner AC, Agrawal M +5

Europe PMC2022
ArticlePsychedelics

Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness.

Kettner H, Rosas FE, Timmermann C +3

Europe PMC2021
ArticlePsychedelics

Self-blinding citizen science to explore psychedelic microdosing.

Szigeti B, Kartner L, Blemings A +5

Europe PMC2021
ArticlePsychedelics

Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing.

Kaertner LS, Steinborn MB, Kettner H +7

Europe PMC2021
ArticleLSD

LSD alters dynamic integration and segregation in the human brain.

Luppi AI, Carhart-Harris RL, Roseman L +3

Europe PMC2021
PreprintLSD

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

Kanen JW, Luo Q, Kandroodi MR +4

Europe PMC2020
ArticlePsychedelics

Pivotal mental states.

Brouwer A, Carhart-Harris RL

Europe PMC2021
ArticleDMT

DMT alters cortical travelling waves.

Alamia A, Timmermann C, Nutt DJ +2

Europe PMC2020
PreprintKetamine

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

Luppi AI, Vohryzek J, Kringelbach ML +16

Europe PMC2020
ArticlePsychedelics

Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation.

Zeifman RJ, Wagner AC, Watts R +3

Europe PMC2020
ArticlePsychedelics

The potential synergistic effects between psychedelic administration and nature contact for the improvement of mental health.

Gandy S, Forstmann M, Carhart-Harris RL +3

Europe PMC2020
PreprintDMT

DMT alters cortical travelling waves

Alamia A, Timmermann C, VanRullen R +1

Europe PMC2020
ArticleLSD

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers.

Family N, Maillet EL, Williams LTJ +6

Europe PMC2020
ArticlePsilocybin

Decreased directed functional connectivity in the psychedelic state.

Barnett L, Muthukumaraswamy SD, Carhart-Harris RL +1

Europe PMC2020
ArticlePsychedelics

From Egoism to Ecoism: Psychedelics Increase Nature Relatedness in a State-Mediated and Context-Dependent Manner.

Kettner H, Gandy S, Haijen ECHM +1

Europe PMC2019
ArticleDMT

Neural correlates of the DMT experience assessed with multivariate EEG.

Timmermann C, Roseman L, Schartner M +13

Europe PMC2019
PreprintPsilocybin

Decreased Directed Functional Connectivity in the Psychedelic State

Barnett L, Muthukumaraswamy SD, Carhart-Harris RL +1

Europe PMC2019
ArticlePsilocybin

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics.

Carhart-Harris RL, Friston KJ

Europe PMC2019
ArticlePsilocybin

Psychedelics as a treatment for disorders of consciousness.

Scott G, Carhart-Harris RL

Europe PMC2019
ArticlePsychedelics

Predicting Responses to Psychedelics: A Prospective Study.

Haijen ECHM, Kaelen M, Roseman L +8

Europe PMC2018
ArticlePsychedelics

Serotonin, psychedelics and psychiatry.

Carhart-Harris RL

Europe PMC2018
ArticlePsilocybin

Psychedelics, Meditation, and Self-Consciousness.

Millière R, Carhart-Harris RL, Roseman L +2

Europe PMC2018
ArticlePsilocybin

Effects of psilocybin therapy on personality structure.

Erritzoe D, Roseman L, Nour MM +4

Europe PMC2018
ArticlePsilocybin

Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression.

Lyons T, Carhart-Harris RL

Europe PMC2018
ArticleLSD

LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.

Timmermann C, Spriggs MJ, Kaelen M +5

Europe PMC2018
ArticlePsilocybin

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.

Carhart-Harris RL, Bolstridge M, Day CMJ +13

Europe PMC2018
ArticlePsychedelics

Serotonin and brain function: a tale of two receptors.

Carhart-Harris RL, Nutt DJ

Europe PMC2017
ArticlePsilocybin

The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future.

Carhart-Harris RL, Goodwin GM

Europe PMC2017
ArticlePsilocybin

Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin.

Schartner MM, Carhart-Harris RL, Barrett AB +2

Europe PMC2017
ArticlePsychedelics

Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI).

Nour MM, Evans L, Nutt D +1

Europe PMC2016
ArticleLSD

LSD-induced entropic brain activity predicts subsequent personality change.

Lebedev AV, Kaelen M, Lövdén M +4

Europe PMC2016
ArticleLSD

LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.

Roseman L, Sereno MI, Leech R +6

Europe PMC2016
ArticleLSD

Neural correlates of the LSD experience revealed by multimodal neuroimaging.

Carhart-Harris RL, Muthukumaraswamy S, Roseman L +23

Europe PMC2016