Martinotti G

Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.

1 preprint · 38 papers · ORCID

PreprintKetamine

Intranasal Esketamine for Treatment-Resistant Depression: A Practical Clinical Guide to Patient Selection, Dosing, Combination Strategies and Adverse-Event Management

De Berardis D, Barlattani T, Carano A +10

Europe PMC2026
ArticleKetamine

Suicidal ideation covaries with depressive severity during six-month real-world esketamine treatment in a cohort enriched for borderline personality disorder.

Martiadis V, Raffone F, Mazzoni F +6

Europe PMC2026
ArticleKetamine

Dimensional effect profiles in treatment-resistant depression: A naturalistic, prospective head-to-head comparison of arTMS, esketamine nasal spray, and oral brexpiprazole.

d'Andrea G, Cavallotto C, Susini O +10

Europe PMC2026
ArticleKetamine

Treatment and management approaches for ketamine misuse: A systematic review of medical interventions.

Mosca A, Chiappini S, Miuli A +9

Europe PMC2026
ArticlePsychedelics

Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.

Pettorruso M, d'Andrea G, Inserra A +12

Europe PMC2026
ArticleKetamine

Intranasal esketamine in treatment-resistant depression with and without comorbid borderline personality disorder: A multicenter real-world longitudinal study.

Mazzoni F, Raffone F, De Ciechi A +6

Europe PMC2026
ArticleKetamine

Functional outcomes with esketamine in treatment-resistant depression: A 6-month multicenter real-world study.

Guglielmo R, Olivola M, Inuggi A +9

Europe PMC2026
ArticleKetamine

Esketamine in treatment-resistant depression with and without comorbid borderline personality disorder: A real-world longitudinal study of suicidal ideation and self-harm.

Raffone F, Mazzoni F, De Ciechi A +6

Europe PMC2026
ArticleKetamine

Narrative Experiences of Esketamine-Induced Dissociation in Patients with Treatment-Resistant Depression: A Qualitative Exploratory Study.

Olivola M, Prodi T, Versaci G +9

Europe PMC2026
ArticleKetamine

Personalizing esketamine treatment in TRD and TRBD: the role of mentalization, cognitive rigidity, psychache, and suicidality.

Olivola M, Mazzoni F, Tarantino B +12

Europe PMC2025
ArticlePsychedelics

Substance-Specific Treatment Responses and Resistance Patterns in Induced Psychoses: A Scoping Review of Antipsychotic Efficacy.

Ricci V, Chiappini S, Martinotti G +1

Europe PMC2025
ArticleKetamine

Esketamine and Quality of Life Improvement in Treatment-Resistant Depression Patients: A Real-World Clinical Study.

Lupi M, Carano A, Acciavatti T +9

Europe PMC2026
ArticleKetamine

Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes.

d'Andrea G, Chiappini S, Ciavoni L +13

Europe PMC2025
ArticleKetamine

Use of Esketamine NS in Treatment-Resistant Depression/Gambling Disorder Comorbidity: A Case Report.

Lupi M, Carano A, Acciavatti T +3

Europe PMC2026
ArticleKetamine

Mentalization and Emotional-Cognitive Rigidity as predictors of esketamine's effects on Treatment-Resistant Depression: Findings from a prospective observational study.

Olivola M, Mazzoni F, Tarantino B +11

Europe PMC2026
ArticleKetamine

Exploring the Influence of Personality Traits on Response to Esketamine nasal spray in Treatment-Resistant Depression: A Real-World Study

Marino M, Briasco E, Guglielmo R +7

Europe PMC2025
ArticlePsilocybin

Endocannabinoids, depression, and treatment resistance: Perspectives on effective therapeutic interventions.

Rosa I, Padula LP, Semeraro F +11

Europe PMC2025
ArticleKetamine

Predictors of Esketamine Response in Treatment-Resistant Depression: The Role of Temperament and Cumulative Treatment Resistance.

Guglielmo R, Marino M, Briasco E +9

Europe PMC2025
ArticleKetamine

Effectiveness of repeated Esketamine nasal spray administration on anhedonic symptoms in treatment-resistant bipolar and unipolar depression: A secondary analysis from the REAL-ESK study group.

d'Andrea G, Cavallotto C, Pettorruso M +25

Europe PMC2025
ArticleKetamine

Patient Experience with Intranasal Esketamine in Treatment-Resistant Depression: Insights from a Multicentric Italian Study (REAL-ESKperience).

Di Nicola M, Pepe M, d'Andrea G +26

Europe PMC2025
ArticleKetamine

Psychotic-Like Experiences in Young Recreational Users of Ketamine: A Case Study.

Ricci V, De Berardis D, Shoib S +2

Europe PMC2026
ArticleKetamine

The Potential Influence of Associated Antidepressants on the Pharmacokinetic Profile of Esketamine in Patients Affected by Treatment-resistant Depression.

Alborghetti M, Lionetto L, Lombardozzi G +16

Europe PMC2025
ArticleKetamine

Esketamine Treatment Trajectory of Patients with Treatment-Resistant Depression in the Mid and Long-Term Run: Data from REAL-ESK Study Group.

Rosso G, d'Andrea G, Barlati S +15

Europe PMC2025
ArticleKetamine

Comparative safety of prescribed Esketamine and ketamine in relation to renal and urinary disorders: A pharmacovigilance perspective.

Chiappini S, Guirguis A, Schifano N +9

Europe PMC2025
ArticleKetamine

Exploring vortioxetine combination with intranasal esketamine: A feasible alternative to SSRI/SNRI? - Insights from the REAL-ESK study.

d'Andrea G, Miuli A, Pettorruso M +12

Europe PMC2024
ArticleKetamine

The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data.

d'Andrea G, Pettorruso M, Di Lorenzo G +16

Europe PMC2024
ArticleMDMA

MDMA-Based Psychotherapy in Treatment-Resistant Post-Traumatic Stress Disorder (PTSD): A Brief Narrative Overview of Current Evidence.

Riaz K, Suneel S, Hamza Bin Abdul Malik M +8

Europe PMC2023
ArticleLSD

LSD-induced changes in the functional connectivity of distinct thalamic nuclei.

Delli Pizzi S, Chiacchiaretta P, Sestieri C +10

Europe PMC2023
ArticleKetamine

Exploring the potential of a bridge therapy: Synergistic approach integrating intravenous ketamine and intranasal esketamine for treatment-resistant depression.

d'Andrea G, Pettorruso M, Rhee TG +3

Europe PMC2023
ArticleKetamine

Exploring the potential of Esketamine in the treatment of bipolar depression.

Dell'Osso B, Martinotti G

Europe PMC2023
ArticleKetamine

Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING).

Pettorruso M, Guidotti R, d'Andrea G +25

Europe PMC2023
ArticleKetamine

Investigating the Effectiveness and Tolerability of Intranasal Esketamine Among Older Adults With Treatment-Resistant Depression (TRD): A Post-hoc Analysis from the REAL-ESK Study Group.

d'Andrea G, Chiappini S, McIntyre RS +12

Europe PMC2023
ArticleKetamine

Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study.

Chiappini S, d'Andrea G, De Filippis S +10

Europe PMC2023
ArticleKetamine

Rethinking ketamine and esketamine action: Are they antidepressants with mood-stabilizing properties?

d'Andrea G, Pettorruso M, Lorenzo GD +3

Europe PMC2023
ArticleKetamine

Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment-resistant depression.

Martinotti G, Dell'Osso B, Di Lorenzo G +23

Europe PMC2023
ArticleIbogaine

Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature.

Mosca A, Chiappini S, Miuli A +8

Europe PMC2023
ArticlePsychedelics

The Benzydamine Experience: A Systematic Review of Benzydamine Abuse.

Chiappini S, Miuli A, Mosca A +6

Europe PMC2021
ArticleKetamine

Therapeutic Potentials of Ketamine and Esketamine in Obsessive-Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature.

Martinotti G, Chiappini S, Pettorruso M +8

Europe PMC2021
ArticleLSD

Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives.

Martinotti G, Santacroce R, Pettorruso M +5

Europe PMC2018