Roth BL
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. bryan_roth@med.unc.edu.
ArticlePsilocybin
A suite of engineered mice for interrogating psychedelic drug actions.
PreprintPsychedelics
No evidence for direct physical interaction of 5-HT <sub>2A</sub> -mGluR2 receptors <i>in vitro</i> or <i>in vivo</i>
ArticlePsilocybin
Psychedelic compounds directly excite 5-HT<sub>2A</sub> layer V medial prefrontal cortex neurons through 5-HT<sub>2A</sub> Gq activation.
ArticlePsilocybin
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
ArticlePsychedelics
The structural diversity of psychedelic drug actions revealed.
ArticlePsychedelics
Making Sense of Psychedelics in the CNS.
ArticleLSD
The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.
PreprintPsilocybin
A suite of engineered mice for interrogating psychedelic drug actions
ArticlePsychedelics
G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.
ArticlePsychedelics
Psychedelics: preclinical insights provide directions for future research.
PreprintPsilocybin
Psychedelic compounds directly excite 5-HT <sub>2A</sub> Layer 5 Pyramidal Neurons in the Prefrontal Cortex through a 5-HT <sub>2A</sub> Gq -mediated activation mechanism
ArticlePsychedelics
The neural basis of psychedelic action.
ArticlePsychedelics
Bespoke library docking for 5-HT<sub>2A</sub> receptor agonists with antidepressant activity.
ArticleLSD
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
ArticlePsilocybin
The promises and perils of psychedelic pharmacology for psychiatry.
ArticlePsilocybin
Molecular insights into psychedelic drug action.
ArticleLSD
LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.
PreprintLSD
Genetic deletion of β-arrestin 2 modulates LSD-stimulated behaviors in mice
PreprintLSD
LSD’s effects are differentially modulated in arrestin knockout mice
ArticlePsilocybin
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT<sub>2A</sub> Serotonin Receptor.
ArticlePsychedelics