Clinical trial
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
Abstract
The overarching aim of this research is to determine the acute effects of ketamine on brain glutamate, functional connectivity and cerebral blood flow in treatment-resistant depression, explore whether the effects are attenuated by the opioid receptor antagonist naltrexone and relate these findings to antidepressant response.
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