An EEG-based evaluation of antidepressant effects of ketamine enantiomers and metabolites in monkeys.

Abstract

Ketamine has shown promise as a rapid-acting antidepressant, but its mechanisms of action and optimal formulation remain incompletely understood. Iwamura et al. (<i>J Neurophysiol</i> 135: 935-950, 2026) used electroencephalography (EEG), a measure of brain electrical activity, to compare how ketamine enantiomers and metabolites differ in their effects on brain activity in a primate model. This mini-review summarizes their findings and examines how this work may inform future research and advance understanding of ketamine-based treatments for depression.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

Keywords