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Preregistration

Baseline HRV predicts bidirectional treatment response in major depressive disorder: high-HRV patients respond better to psilocybin, low-HRV patients respond better to SSRIs

OSFMar 18, 2026

Abstract

This preregistration documents a specific quantitative prediction derived from the precision dynamics framework prior to any analysis of clinical datasets. The prediction was generated from a coupled ODE system implementing the CANAL framework (Carhart-Harris et al. 2022) and is described in the repository at github.com/gabrielmanhaes/precision-dynamics

Topics & conditions

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PsilocybinDepression

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