Clinical trial

Emotional Effects of Methylphenidate and MDMA in Healthy Subjects

University Hospital, Basel, SwitzerlandCompletedPhase 1Started Dec 1, 201116 enrolledSwitzerlandNCT01465685

Abstract

This study compares the interactive emotional/subjective effects of single doses of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and methylphenidate, a dopamine (DA) and norepinephrine (NE) transporter blocker, in healthy subjects. The primary goal is to determine the role of transporter mediated DA and NE release in the subjective response to MDMA in humans. The investigators hypothesize that methylphenidate will attenuate the subjective response to MDMA.

Topics & conditions

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MDMA

Keywords

pharmacokineticspharmacodynamicsemotionsMechanism of action of MDMAInteraction studyEffect of MDMA and methylphenidate on emotionsHealthy

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