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Peer-reviewed article

Transient or transformative? Psychedelics, agency and informed consent.

Caporuscio CiD

Journal of medical ethicsMar 10, 2026Germany0 citationsDOI: 10.1136/jme-2025-111248

Abstract

The literature on psychedelic experiences often highlights their transformative potential. This raises ethical questions about informed consent in psychedelic-assisted therapy: if the altered state of consciousness induced by psychedelic drugs can profoundly alter a person's value system in ways that are epistemically inaccessible to them beforehand, it is unclear whether their informed consent before the experience can be considered valid. I argue that this view stems from a simplistic understanding of psychedelic-mediated transformation, which overemphasises the power of the psychedelic experience in driving change. In most psychedelic-mediated changes, the experience of an altered state of consciousness is only the beginning of the transformative process: a lasting transformation requires patients to undertake a sober, authentic agential process following the psychedelic experience. I suggest that this two-step view of psychedelic transformation alleviates the pressure on informed consent.

Topics & conditions

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Psychedelics

Keywords

PsychiatryInformed consentPsychopharmacologypsychotherapy

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