Intravenous S-ketamine in neuropathic pain: a scoping review of exposure patterns, clinical response, and safety
Abstract
Intravenous S-ketamine (esketamine) has been investigated in neuropathic pain using markedly heterogeneous administration strategies, including short fixed-duration infusions, prolonged continuous infusions, multi-day titration, repeated treatment, and patient-controlled intravenous analgesia. Existing reviews have primarily evaluated ketamine as a broader pharmacological class and have focused on analgesic efficacy. The specific clinical evidence for intravenous S-ketamine, particularly with respect to administration and exposure patterns, timing of clinical response, safety, and reproducibility of treatment protocols, has not been systematically mapped. This scoping review will characterize the available clinical evidence for intravenous S-ketamine in neuropathic pain, map how different exposure patterns have been implemented and reported, summarize clinical responses and safety outcomes according to their assessment time points, and identify methodological and reporting gaps that limit cross-study interpretation and future dose-optimization trials.
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