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Peer-reviewed article

An ETH-LAD trip with unfavourable consequences: A case report.

Nadler JiD, Sommer M, Zschiesche AiD, Stürzebecher A, Grumann C, Auwärter V, Hermanns-Clausen M

British journal of clinical pharmacologyAug 7, 2026Germany0 citationsDOI: 10.1002/bcp.70776

Abstract

Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH-LAD (6-ethyl-6-nor-lysergic acid diethylamide), the N-ethyl derivative of LSD. An adolescent patient developed moderate to severe symptoms as acute aggression, agitation, unconsciousness, multiple traumatic injuries, metabolic disturbances and persistent psychosis following ETH-LAD ingestion and required intensive medical therapy with unexpected findings. The concentration of the hallucinogenic new psychoactive substance in serum was determined with 38 ng mL<sup>-1</sup>. After 17 days of hospitalization, the patient was transferred to a psychiatric clinic for further treatment. Physicians must be aware that ETH-LAD ingestion may, unlike LSD, lead to severe toxic effects, requiring intensive care.

Topics & conditions

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LSDPTSD

Keywords

Drug abuseHallucinogenNew Psychoactive Substance (Nps)Lc‐ms/msOverdose And Poisoning

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