Rapid effects of MDMA administration on self-reported personality traits and affect states: A randomized, placebo-controlled trial in healthy adults
Abstract
Evidence indicates that psychedelic drugs, such as MDMA, psilocybin, or LSD, may result in changes in personality traits, including the trait domains of the Five Factor Model (FFM) of personality, namely increased Openness (for review, see Bouso et al., 2018) as well as increased Extraversion and decreased Neuroticism (Erritzoe et al., 2018). Some of these personality changes have been demonstrated to persist for over a year following psychedelic administration (i.e., Openness; MacLean et al., 2011). To date, much of the research consists of observational studies or clinical trials in psychiatric samples. For example, in a study of the mechanism of change for MDMA-assisted therapy for posttraumatic stress disorder (PTSD; Wagner et al., 2017), the intervention resulted in increased Openness and decreased Neuroticism. MDMA has also been shown to be associated with changes in mood and emotions, including increasing aspects of positive affect and decreasing aspects of negative affect (e.g., Dolder et al., 2018). However, there has been less investigation of the personality impact of MDMA and the impact of psychedelics on personality traits in healthy and non-psychiatric samples. Thus, the present study (N = 34) aims to investigate the impact of MDMA administration on affect and FFM traits in a placebo-controlled trial conducted among psychiatrically and medically healthy adults.
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