Ketamine versus Etomidate as Induction Agent for Rapid Sequence Intubation in Critically Ill Adults: A Systematic Review and Meta-Analysis

Abstract

Systematic review and meta-analysis of randomized controlled trials comparing ketamine versus etomidate as induction agents for rapid sequence intubation (RSI) in critically ill adults. Primary outcome: peri-intubation cardiovascular collapse. Secondary outcomes: 28-day mortality, post-intubation hypotension, vasopressor use, and adrenal insufficiency. Subgroup analysis planned for patients with sepsis. Conducted in accordance with PRISMA 2020 guidelines.

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