Mystical Experience as a Partial Mediator of Psychedelic Outcomes via Network Integration
Abstract
Narrative review + mediation model: entheogen → mystical/noetic experience → network-level reconfiguration → clinical outcomes; integrating RCTs, psychometrics (MEQ/EBI), and neuroimaging. This preregistration documents a narrative review and mediation model: entheogen → mystical/noetic experience → network-level brain change → clinical outcomes. Sources include psilocybin, LSD, and related trials. Registration freezes our causal pathway hypothesis before writing.
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