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Peer-reviewed article

Oncology Providers' Perspectives on Psychedelic-Assisted Therapy.

Hanubal KSiD, Munjal AN, Park J, Banks R, Choi E, Hoyt MA, Humphreys JN, Mojtahedzadeh M, Harris JP

The American journal of hospice & palliative careAug 28, 2026United States0 citationsDOI: 10.1177/10499091261483604

Abstract

PurposeDespite most psychedelic substances remaining Schedule I, clinical research exploring psychedelic-assisted therapy (PAT) in oncology is expanding. We sought to assess oncology providers' attitudes toward and understanding of PAT.MethodsWe conducted a cross-sectional survey of healthcare professionals involved in oncology across five academic institutions in California, South Carolina, and Florida, and one nonacademic institution in Georgia. The survey was also distributed to 4500 members of the American Academy of Hospice and Palliative Medicine. Items assessed demographics, familiarity and concerns regarding psychedelic medications, and willingness to recommend PAT based on case-based scenarios.ResultsOf 5084 surveyed, 385 responded (8% response rate). Most respondents (85%) were palliative care physicians. Only 44% were familiar with the legal and regulatory status of psychedelic agents. While 49% had received patient inquiries about PAT, 80% did not feel comfortable counseling patients on its use. Primary concerns included unknown drug interactions with cancer therapies and safety in the setting of oncologic comorbidities. Factors encouraging future PAT adoption included increased education and access to experienced treatment centers. On multivariate analysis, willingness to recommend PAT was associated with familiarity with emerging PAT data, knowledge of the legal and regulatory status of psychedelics, and prior patient inquiry about PAT. Provider age, specialty, and other clinicodemographic factors were not significant predictors.ConclusionMany oncology providers report patient interest in PAT but lack confidence to counsel them. Findings underscore the need for targeted provider education and further clinical research to support informed decision-making about PAT in oncology.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

PsilocybinMDMAKetaminePalliative care

Keywords

OncologyHallucinogensAntidepressantsMental Health DisordersPsychedelics

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