Clinical trial

A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLCCompletedPhase 3Started Oct 1, 2015719 enrolledUnited States, Belgium, Brazil, Canada, Czechia, Estonia, France, Germany, Hungary, Mexico, Poland, Slovakia, Spain, Sweden, Turkey (Türkiye)NCT02493868

Abstract

The purpose of this study is to assess the efficacy of intranasal esketamine plus an oral antidepressant compared with an oral antidepressant (active comparator) plus intranasal placebo in delaying relapse of depressive symptoms in participants with treatment-resistant depression (TRD) who are in stable remission after an induction and optimization course of intranasal esketamine plus an oral antidepressant.

Topics & conditions

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KetamineDepression

Keywords

Treatment-resistant DepressionEsketaminePlaceboOral AntidepressantRelapse preventionDepressive Disorder, Treatment-Resistant

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