Clinical trial

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Usona InstituteCompletedPhase 1Started Dec 27, 202254 enrolledUnited StatesNCT05698095

Abstract

The primary objective of the study is to assess the pharmacokinetics, safety, and tolerability of a single-dose and multiple-doses of 5-MeO-DMT administered by intramuscular (IM) injections in healthy subjects.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

DMT

Keywords

5-MeO-DMTPsychedelicsSafetyPharmacokineticsFirst-in-human5-methoxy-N,N-dimethyltryptaminePharmacokineticsSafetyTolerability

View on registry

Psychedelic Commons aggregates metadata from open sources and links back to the original. Rights remain with the authors and publishers. Something wrong with this record? Report a problem.

This study's objects

Directly linked records, matched by DOI, trial reference, or registry, not just topic.

Publications from this trial

Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.

Shen HW, Jiang XL, Winter JC +1

The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption.

Davis AK, Barsuglia JP, Lancelotta R +2

ArticlePsilocybin

Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study.

Barsuglia J, Davis AK, Palmer R +6

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.

Uthaug MV, Lancelotta R, van Oorsouw K +10

Synthesis and Characterization of 5-MeO-DMT Succinate for Clinical Use.

Sherwood AM, Claveau R, Lancelotta R +2

A narrative synthesis of research with 5-MeO-DMT.

Ermakova AO, Dunbar F, Rucker J +1

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers.

Reckweg J, Mason NL, van Leeuwen C +3

Related research

ArticlePsilocybin

Race and Gender Differences in the Moderating Relationship of Psychedelics on Stigma and Distress.

Viña SM

ArticleAyahuasca

Analysis of 28 hair samples from users of the hallucinogenic beverage ayahuasca.

Liu M, Yang H, Hu J +6

ArticleAyahuasca

Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil.

Souza RCZ, Zandonadi FS, Freitas DP +2