KETAMINE FOR ACUTE PAINFUL SICKLE CELL CRISIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Abstract
This project presents a meta-analysis examining the efficacy and safety of ketamine for managing acute pain during vaso-occlusive crises (VOCs) in patients with sickle cell disease. The review includes randomized controlled trials and observational studies that compare ketamine with standard analgesics or placebo. The primary outcomes of interest were changes in pain scores and opioid consumption, while secondary outcomes consisted of adverse events and hospital admissions By synthesizing current evidence, this study aims to inform clinical guidelines and optimize pain management strategies in sickle cell care. All protocols, search strategies, inclusion criteria, and analysis plans are documented to ensure transparency and reproducibility.
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