Descriptive Evaluation of Hematological and Biochemical Parameters in Dogs Undergoing Dexmedetomidine Continuous Infusion Associated with Esketamine, Isoflurane and Propofol
Abstract
<title>Abstract</title> <p>The hematological, biochemical and glycemic changes related to dexmedetomidine in dogs still require in-depth studies, and their mechanisms have not been fully elucidated. Furthermore, different individuals may present different responses to the pharmacodynamics of the compound in question. The aim of this study was to determine the profile in dogs and compare the results before, during and after continuous infusion. Six healthy dogs received dexmedetomidine (3 µg/kg − 100 µg/mL) with esketamine (3 mg/kg − 50 mg/mL) intramuscularly. After 10 min, a continuous infusion of dexmedetomidine (3 µg/kg/hr) was initiated for 30 min. Venous blood samples were collected through the jugular vein at times T0’ (before the administration of the drug), T15’ and T30’ (15 and 30 min following the initiation of the infusion) and T120’ (90 min after the end of the infusion). The results were analyzed in a specialized laboratory taking into account the reference values for the species. The parameters verified were total erythrocytes, hematocrit, hemoglobin, total leukocytes, total proteins, alanine transferase, alkaline phosphatase, plasma urea and blood glucose. In conclusion, the proposed protocol induced transient hyperglycemia to a maximum mean of 149.4 ± 35.4 mg/dL, as well as decreased values in erythrocytes (5.86 ± 0.82 million µL) and hemoglobin (13.4 ± 2.0 g/dL), with no significant changes in the others parameters.</p>
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