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Peer-reviewed article

Set and setting predict psychopathology, wellbeing and meaningfulness of psychedelic experiences: a correlational study.

Borkel LFiD, Rojas-Hernández JiD, Henríquez-Hernández LAiD, Santana Del Pino ÁiD, Quintana-Hernández DJiD

Expert review of clinical pharmacologyJan 29, 2024Spain23 citationsDOI: 10.1080/17512433.2023.2295997

Abstract

<h4>Background</h4>In psychedelic therapy, the importance of set and setting is a fundamental but under-researched assumption. The aim of this study is to correlate variables of set (psychedelic use motivation) and setting (psychedelic use location and type of companion) with psychopathology, wellbeing and personality variables.<h4>Research design and methods</h4>A sample of 1022 participants of the Spanish-speaking population was collected through an online survey. A novel instrument, the Psychedelic Use Scale (PUS), was developed to measure substance use variables of LSD, mescaline, psilocybin, DMT, 5-Meo-DMT, ketamine, <i>Salvia divinorum</i>, ibogaine and MDMA. Various personality, well-being and psychopathology instruments were implemented to measure outcome variables.<h4>Results</h4>Growth motivations, natural settings and presence of significant others predicted less psychopathology, greater wellbeing and meaningfulness of psychedelic experiences, whereas problematic motivations predicted greater psychopathology, lower wellbeing and did not predict meaningfulness of psychedelic experiences.<h4>Conclusions</h4>Based on these results, we suggest experimental hypotheses for future clinical trials and longitudinal studies with potential clinical implications.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

PsilocybinMDMAKetamineLSDIbogaineDMT5-MeO-DMTMescalineAddiction

Keywords

SurveyMental healthPsychopathologyDrug UsePsychedelicsSpanish-speaking Population

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