Changes in brain entropy after psilocybin treatment in people with treatment resistant depression
Abstract
Background Treatment resistant depression (TRD) poses a major problem in psychiatry with prevalence rates above 50% in patients diagnosed with major depression (MDD). Given the modest efficacy of classic antidepressant treatments in addition to many further downsides like, requiring several weeks to take effect, non-negligible side effects, discontinuation problems, high relapse rates and the scarcity of innovative approaches (Cipriani et al., 2018; Haddad, 1998; Hofmann et al., 2017; Locher et al., 2017; Steinert et al., 2014) the interest in psychedelic assisted therapy has grown. Preliminary evidence for the efficacy and safety of psilocybin in the treatment of MDD and TRD has been accumulating in recent studies (Carhart-Harris et al., 2021; Carhart-Harris et al., 2018; Carhart-Harris et al., 2016; Davis et al., 2021). However, the neurobiological effects are not completely understood and a current field of interest. In our study we aim to contribute to the understanding of the neurobiological effects of psilocybin-assisted therapy, by applying signal theoretical measures like entropy measures (Lebedev et al., 2016) to functional Magnetic Resonance Imaging (fMRI) data of people with TRD undergoing therapy with 25 mg psilocybin in a randomized controlled trial. Expanding the knowledge in this domain can be conducive to comprehending the antidepressant effects of psychedelics in greater depth. Contributors Christian Schmitz, Hana Adolphi, Lea J. Mertens, Gerhard Gründer License No license Tags Medicine and Health Sciences: Psychiatry and Psychology: Mental Disorders Medicine and Health Sciences: Analytical, Diagnostic and Therapeutic Techniques Medicine and Health Sciences: Medical Sciences: Medical Neurobiology Medicine and Health Sciences: Medical Sciences: Medical Pharmacology
Topics & conditions
Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.
Psychedelic Commons aggregates metadata from open sources and links back to the original. Rights remain with the authors and publishers. Something wrong with this record? Report a problem.