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Peer-reviewed article

Toward Precision Psychedelic Therapies: Chemical, Computational, and Neuromodulatory Innovations.

Renner ACiD, Kargbo RBiD

ACS medicinal chemistry lettersOct 9, 2025United States0 citationsDOI: 10.1021/acsmedchemlett.5c00597

Abstract

Recent patents disclose complementary strategies to optimize psychedelic-assisted therapy. Novel psilocin prodrugs improve pharmacokinetics and stability, while digital systems enable cognitive state monitoring during treatment. Parallel advances in combining neuroplastogen drugs with transcranial electrical stimulation highlight a model-driven approach to enhance and personalize neural plasticity. Together, these innovations converge on a precision framework for treating neuropsychiatric disorders.

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Psilocybin

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