COGNITIVE-ENHANCING EFFECT OF ETHYL ACETATE FRACTION OF ERYTHROPHLEUMIVORENSE STEMS BARK AGAINST KETAMINE-INDUCED MEMORY IMPAIRMENT IN MICE

Abstract

Background :Conventional treatments for managing Alzheimers disease (AD) and related cognitive deficits are not said to be curative; they relieve symptoms but can result in adverse side effects. Additionally, the use of herbal therapies to manage cognitive illnesses has increased significantly. Erythrophylum ivorense is commonly used in herbal medicine to manage neurological disorders. The present study evaluated the cognitive-enhancing potential of the ethyl acetate fraction of Erythrophleum ivorense (EAFEI) against ketamine-induced memory impairment in mice. Materials and Methods:  Ketamine (15 mg/kg) was administered to Induce memory impairment.Donepezil (1 mg/kg) served as thestandard reference compound.An ethyl acetate fraction of Erythrophleumivorense (20, 40, 80 mg/kg) was evaluated for its cognitive enhancing effects, as by step through latency in a passive avoidance test.Additionally, the anti acetylcholinesterase (anti AChE) activity and antioxidant potential of the extract were assessed using brain tissues from the test animals transmission.  

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

Keywords