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Clinical trial

The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects

Yale UniversityCompletedStarted Aug 1, 200816 enrolledUnited StatesNCT01600885

Abstract

The purpose of the study is 1. To establish the feasibility of fMRI studies of the interaction of guanfacine and ketamine. 2. To explore the possibility that guanfacine can ameliorate the negative effects of ketamine on task-related prefrontal activation. 3. To assess the strength of any interaction between guanfacine and ketamine.

Topics & conditions

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Ketamine

Keywords

GuanfacineFunctional Magnetic Resonance ImagingPrefrontal Cortex ActivityReceptors, N-Methyl-D-AspartateReceptors, Adrenergic, alpha-2Memory, Short-TermSchizophreniaNMDA Receptor Function

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