Ketamine and Adolescent Depression: A Scoping Review Protocol of Benefits, Risks and Future Research Directions
Abstract
Unipolar major depressive disorder (MDD) is becoming increasingly prevalent, reflecting a concerning surge in its incidence rates thus attributing this era to “an epidemic of depression”. Studies have shown that MDD is now 34% likely to show up in adolescents globally and is considered to be responsible for almost 8% of completed suicides among this population making it the second leading cause of death in young adults thus making it a public health imperative that cannot be overlooked. While conventional treatments modalities benefit many, a notable proportion of adolescents remain treatment-resistant, necessitating exploration of alternative interventions. Ketamine, classically an anesthetic, shows promise for treatment resistant depression among adults, with recent trials indicating efficacy in adolescents. Existing reviews on ketamine's use in depression have primarily focused on adult populations only. Therefore, this scoping review will address a critical gap in the literature by examining the evidence of ketamine use in adolescents with depression and suicidal ideation.
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