Clinical trial

Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia

Peking University First HospitalCompletedPhase 4Started Apr 9, 2021200 enrolledChinaNCT04791059

Abstract

Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and dexmedetomidine in combination with opioids may have synergistic effect in analgesia and reduce drug-related side effects. This study aims to explore the effect of low-dose of S-ketamine and dexmedetomidine in combination with opioids for postoperative patient-controlled intravenous analgesia in patients following scoliosis correction surgery.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

KetaminePain

Keywords

Scoliosis correctionPostoperative analgesiaS-ketamineDexmedetomidineSufentanilScoliosis CorrectionPostoperative AnalgesiaS-ketamineDexmedetomidineSufentanil

View on registry

Psychedelic Commons aggregates metadata from open sources and links back to the original. Rights remain with the authors and publishers. Something wrong with this record? Report a problem.