Clinical trial

-Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic Polymorphisms

Parc de Salut MarCompletedPhase 1Started May 1, 200327 enrolledSpainNCT01447472

Abstract

The purpose of this study are: 1. to evaluate the involvement of CYP2D6, CYP3A4 and CYP1A2 (through dextromethorphan and caffeine challenges), and catechol-O-methyltransferase (COMT)in MDMA metabolism 2. to evaluate gender differences in the human pharmacology of MDMA 3. to study the influence of some genetic polymorphisms (CYP2D6, COMT, SERT) in the effects and pharmacokinetics of MDMA.

Topics & conditions

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MDMA

Keywords

MDMA,pharmacokinetics,pharmacodynamics,CYP2D6, COMT,SERT, 5-HTTLPR, gender,dextromethorphan,caffeine.MetabolismInteraction

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