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Peer-reviewed article

[Intravenous ketamine in suicidal crisis : indications and patient referral].

Nasserdine RiD, Xhymshiti L, Paporé AC, Marini V, Tsartsalis S, Richard-Lepouriel H

Revue medicale suisseSep 1, 20260 citationsDOI: 10.53738/revmed.2026.22.975.49121

Abstract

Intravenous (IV) ketamine is a rapidly acting therapeutic option for the management of treatment-resistant depression and acute suicidal crisis. Unlike conventional antidepressants, its effects may occur within hours, allowing a rapid reduction in suicidal ideation and psychological distress. Its use remains specialized and requires hospital-based care with medical monitoring and a comprehensive psychiatric assessment. This article provides a practical overview for primary care physicians, focusing on the indications, referral criteria, and role of IV ketamine within the care pathway of patients with treatment-resistant depression or acute suicidal crisis, illustrated by a clinical vignette.

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KetamineDepression

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