The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line.

Abstract

Ayahuasca, a psychoactive beverage native to the Amazon, originally derived from <i>Banisteriopsis caapi</i> stem scrapings and <i>Psychotria viridis</i> leaves, exhibits hallucinogenic properties due to <i>N,N</i>-dimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This study assessed the impact of extracts from three plant decoctions used in ayahuasca preparation on the gastric adenocarcinoma cell line (AGS). MTT reduction assays selected <i>B. caapi</i>, <i>Mimosa hostilis</i>, and <i>Peganum harmala</i> samples as most effective. Lactate dehydrogenase activity evaluated membrane integrity loss, while oxidative stress induction was measured using dihydroethidium and 2',7'-dichlorodihydrofluorescein diacetate probes. Results revealed apoptosis induction in AGS cells, with all three samples significantly reducing oxidative stress.

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