Effect of single intravenous injection of esketamine on quality of recovery during early period after modified radical mastectomy for breast cancer: A retrospective study.
Abstract
<h4>Objective</h4>To assess the impact of a single esketamine intravenous (IV) injection on the quality of recovery during early period after modified radical mastectomy for breast cancer.<h4>Methods</h4>This retrospective study included 80 patients who underwent modified radical mastectomy under general anesthesia in Huzhou Maternity & Child Health Care Hospital from March to October 2022. All patients were between 35 to 55 years, weighting between 45 and 70 kg and Grade-I or II according to the American Society of Anesthesiologists (ASA). Patients were grouped based on the type of pain management used. Patients (n=40) who were given 0.25 mg/kg esketamine single IV injection prior to completion of the surgery were assigned to Group-E, and patients (n=40) who were not treated with esketamine, comprised the control Group-C. Patients' data, such as education years, operation time, blood loss, the 9-item Quality of Recovery (QoR-9) scores before the anesthesia induction (T<sub>0</sub>), one (T<sub>1</sub>) and two hours after the extubation (T<sub>2</sub>), the 40-item Quality of Recovery (QoR-40) scores one (D<sub>1</sub>) and two days after the surgery (D<sub>2</sub>), and the rate of adverse reactions were assessed in both groups.<h4>Results</h4>Compared with T<sub>0</sub>, the QoR-9 scores at T<sub>1</sub> and T<sub>2</sub> were markedly lower in all patients. Compared to Group-C, the QoR-9 scores at T<sub>1</sub> and T<sub>2</sub> in Group-E were considerably increased (<i>P</i><0.05). Similarly, the QoR-40 scores on D<sub>1</sub> and D<sub>2</sub> in Group-E were significantly higher compared to Group-C (<i>P</i><O.05).<h4>Conclusion</h4>Single intravenous injection of esketamine can improve the quality of the recovery of breast cancer patients during the early period after the modified radical mastectomy.
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