Norpsilocin: freebase and fumarate salt.
Abstract
The solid-state structures of the naturally occurring psychoactive tryptamine norpsilocin {4-hy-droxy-<i>N</i>-methyl-tryptamine (4-HO-NMT); systematic name: 3-[2-(methyl-amino)-eth-yl]-1<i>H</i>-indol-4-ol}, C<sub>11</sub>H<sub>14</sub>N<sub>2</sub>O, and its fumarate salt (4-hy-droxy-<i>N</i>-methyl-tryptammonium fumarate; systematic name: bis-{[2-(4-hy-droxy-1<i>H</i>-indol-3-yl)eth-yl]methyl-aza-nium} but-2-enedioate), C<sub>11</sub>H<sub>15</sub>N<sub>2</sub>O<sup>+</sup>·0.5C<sub>4</sub>H<sub>2</sub>O<sub>4</sub> <sup>2-</sup>, are reported. The freebase of 4-HO-NMT has a single mol-ecule in the asymmetric unit joined together by N-H⋯O and O-H⋯O hydrogen bonds in a two-dimensional network parallel to the (100) plane. The ethyl-amine arm of the tryptamine is modeled as a two-component disorder with a 0.895 (3) to 0.105 (3) occupancy ratio. The fumarate salt of 4-HO-NMT crystallizes with a tryptammonium cation and one half of a fumarate dianion in the asymmetric unit. The ions are joined together by N-H⋯O and O-H⋯O hydrogen bonds to form a three-dimensional framework, as well as π-π stacking between the six-membered rings of inversion-related indoles (symmetry operation: 2 - <i>x</i>, 1 - <i>y</i>, 2 - <i>z</i>).
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