Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding.
Abstract
Psychedelic compounds can induce rapid-acting and long-lasting antidepressant benefits. Understanding the role of their hallucinatory effects is crucial for shaping the future trajectory of antidepressant drug development. Photoswitchable compounds targeting the 5-HT<sub>2A</sub>R offer precise spatio-temporal control over the activation of different downstream pathways. In this work, we computationally discovered PQ-azo-<i>N</i>,<i>N</i>-DMT (34), a photoswitch with improved features compared to the previously synthesized azo-<i>N</i>,<i>N</i>-DMT (1). The new compound shows tight binding to the 5-HT<sub>2A</sub>R, retaining all important interactions of lysergic acid diethylamide (LSD), exhibits positive membrane permeability, and has a strong red-shifted absorption that would allow photocontrol in the visible spectrum.
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