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Clinical trial

Investigation to Understand and Optimize Psilocybin

Charles RaisonRecruitingPhase 2Started May 13, 2025141 enrolledUnited StatesNCT06512194

Abstract

This study will examine the effects of a single dose of psilocybin, administered with psychological support, on symptoms of depression. It will also assess whether different post-dosing interventions, including a non-invasive technique called transcutaneous auricular Vagus Nerve Stimulation (taVNS), influence various psychological and behavioral outcomes. In addition, the study will explore objective measures of real-world social behavior and identify early behavioral responses that may be associated with long-term treatment outcomes.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

PsilocybinDepression

Keywords

psychedelicstranscutaneous auricular vagus nerve stimulationdepressive symptomswell-beingadverse eventsecological momentary assessmentelectronically activated recorderdynamical complexity assessment

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