The anxiolytic-like effect of the alkaloid fraction of the psychedelic plant <i>Mimosa tenuiflora</i> (Willd.) Poir.

Abstract

The present work investigated the anxiolytic effect of the alkaloid fraction (AF II) from the root bark of <i>Mimosa tenuiflora</i>. Female Swiss mice of 6 weeks old were used in this study. The animals were divided into three groups: 0.9% NaCl (vehicle group, s.c.), AF II (6 mg/kg, s.c.), and diazepam - DZP (5 mg/kg, s.c.). The light/dark box and elevated plus maze tests evaluated the animal anxiety. DMT was identified by the HPLC method. AF II showed significant anxiolytic effects in the two behavioural tests used.

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