Tuning reductase activity in monoterpene indole alkaloid biosynthesis

Abstract

<p>Monoterpene indole alkaloids encompass a diverse class of plant natural products. Many of these valuable compounds, including the anticancer medicines vinblastine and vincristine (<em>Catharanthus roseus</em>) and the antiaddiction treatment ibogaine (<em>Tabernanthe iboga)</em> utilize a common biosynthetic intermediate, 19<em>E</em>-geissoschizine, which is produced by the medium-chain dehydrogenase/reductase geissoschizine synthase (GS). This dataset provides the raw data for the genome of <em>Tabernanthe iboga</em>.</p>

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