Clinical trial

Mood Effects of Serotonin Agonists: Depression

University of ChicagoCompletedEarly Phase 1Started Jun 9, 202541 enrolledUnited StatesNCT07017478

Abstract

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Topics & conditions

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LSDDepression

Keywords

Major Depressive Disorder

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This study's objects

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Publications from this trial

Psychedelics Promote Structural and Functional Neural Plasticity.

Ly C, Greb AC, Cameron LP +13

Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers.

Bershad AK, Schepers ST, Bremmer MP +2

ArticlePsilocybin

Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression.

Ling S, Ceban F, Lui LMW +12

ArticlePsilocybin

Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?

Husain MI, Ledwos N, Fellows E +5

ArticlePsilocybin

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.

Moliner R, Girych M, Brunello CA +30

Use of Lysergic Acid Diethylamide by Major Depression Status.

Walsh CA, Gorfinkel L, Shmulewitz D +2

ArticlePsilocybin

Serotonin 2A Receptor (5-HT<sub>2A</sub>R) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants.

Duan W, Cao D, Wang S +1

Microdosing Psychedelics: Current Evidence From Controlled Studies.

Murphy RJ, Muthukumaraswamy S, de Wit H

LSD increases sleep duration the night after microdosing.

Allen N, Jeremiah A, Murphy R +8

Inter-individual variability in neural response to low doses of LSD.

Hutten NRPW, Quaedflieg CWEM, Mason NL +7

Related research

ArticlePsilocybin

MFCC-DFT mapping of ligand recognition at the 5-HT<sub>2A</sub> receptor: energetic analysis of the interactions between serotonin, psychedelics, and antipsychotics.

Junior WSC, Bezerra KS, Matias EGC +2

ArticlePsilocybin

Psychedelics and Mental Health in Endurance Athletes: A Cross-Sectional Study in Brazil.

Portes MAM, Bertoglio LJ

ArticlePsilocybin

Psychedelic experiences elicited by serotonergic psychedelics: Molecular mechanisms and functional connectivity changes in the brain.

Vollebregt R, Storm AEM, Lucassen PJ +1