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Preregistration

Therapeutic Applications of Classic Psychedelics in Comorbid Depression and Substance Use Disorders: A Scoping Review

OSFJul 31, 2025

Abstract

This scoping review aims to systematically map existing literature on the therapeutic use of classic psychedelics (LSD, psilocybin, mescaline, DMT) in depression, substance use disorders (SUDs), and their comorbidity. Using PRISMA-ScR and Joanna Briggs Institute (JBI) frameworks, the review will identify key findings, research gaps, and comparative outcomes across these three clinical domains.

Topics & conditions

Detected automatically by Psychedelic Commons from the title and abstract, not labels from the source. They may be incomplete.

PsilocybinLSDDMTMescalineDepressionAddiction

Keywords

Classic psychedelicsComorbidityDual diagnosisEvidence synthesisPsychedelic-assisted therapyScoping reviewSubstance use disorders
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