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Preregistration

White Matter Microstructure and Psilocybin Treatment for OCD: Baseline Associations, Longitudinal Change, and Link to Symptom Response

OSFOct 13, 2026

Abstract

This project is a secondary analysis of a psilocybin treatment trial for patients with OCD. We examine whether baseline white matter microstructure predicts treatment response, whether white matter microstructure changes from baseline to post-treatment, and whether the magnitude of that change relates to symptom improvement.

Topics & conditions

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PsilocybinOCD

Keywords

clinical psychologypsilocybin pharmacology

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