Psilocybin in neurological disorders: a scoping review protocol
Abstract
Background. Research on psilocybin and psilocin has expanded beyond classic psychiatric indications to neurological disorders such as headache, neuropathic pain, movement disorders, functional neurological disorders, epilepsy, neurodegenerative diseases and disorders of consciousness. The available literature describes a heterogeneous field, with multiple designs, exposure regimens and neurophysiological/neuroimaging tools. Problem. The field remains fragmented: clinical evidence, mechanistic research, safety studies and registered trials are scattered across different conditions, doses and designs. Moreover, this heterogeneity makes it difficult to distinguish which signals have clinical support, which are purely mechanistic and where evidence gaps exist. Objective. To systematically characterize the scope and structure of the clinical and applied evidence on psilocybin/psilocin in non-psychiatric neurological disorders, including population, condition, design, exposure regimen, psychotherapeutic support, outcomes, safety, biomarkers assessed and bibliometric structure. Methods. Scoping review using the PCC framework (Population, Concept, Context), with a multi-database search, a trial-registry search to locate publications, two-stage selection, standardized and piloted extraction, descriptive synthesis and descriptive bibliometric analysis as a secondary component. Risk of bias and methodological quality will be assessed with design-specific tools as a secondary layer, separate from the inclusion decision. Expected result. An evidence map by condition, intervention type and outcome; a safety synthesis; a description of the biomarkers assessed; and a bibliometric description of the scientific output, with co-authorship and thematic co-occurrence networks if the size of the corpus allows.
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