MDMA/ecstasy use and psilocybin use are associated with lowered odds of psychological distress and suicidal thoughts in a sample of US adults.

Abstract

<h4>Background</h4>Suicide is one of the leading causes of death worldwide and rates within the United States have risen over the past two decades. Hence, there is a critical need for novel tools to treat suicidal ideation and related mental health conditions. 3,4-Methylenedioxymethamphetamine (MDMA)/ecstasy and classic psychedelics may be two such tools.<h4>Aims</h4>The aim of this study was to assess non-causal associations between MDMA/ecstasy and classic psychedelic use and psychological distress and suicide risk.<h4>Methods</h4>In this study, we examined the aforementioned associations among 484,732 adult participants in the National Survey on Drug Use and Health (2008-2019).<h4>Results</h4>Lifetime MDMA/ecstasy use was associated with reduced odds of past year suicidal thinking (10% reduced odds; odds ratio (OR) = 0.90; 95% confidence interval, CI = (0.84-0.97); <i>p</i> < 0.01) and past year suicidal planning (OR = 0.88; 95% CI = (0.78-0.99); <i>p</i> < 0.05). Furthermore, lifetime psilocybin use was associated with reduced odds of past month psychological distress (OR = 0.78; 95% CI = (0.73-0.84); <i>p</i> < 0.001) and past year suicidal thinking (OR = 0.90; 95% CI = (0.83-0.96); <i>p</i> < 0.01). Finally, lysergic acid diethylamide (LSD) was associated with <i>increased</i> odds of past year suicidal thinking (OR = 1.07; 95% CI = (1.00-1.15); <i>p</i> < 0.05).<h4>Conclusion</h4>MDMA/ecstasy and psilocybin use are associated with reduced odds of suicidal thinking and related outcomes-though experimental studies are needed to determine whether these associations are causal. These findings call for more research into the efficacy of MDMA/ecstasy and classic psychedelics for treating psychological distress and suicidal thoughts and behaviors, and for updated drug legislation that allows for further investigation into these substances.

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