Peer-reviewed articleOpen access

Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity.

Chadeayne AR, Pham DNK, Reid BG, Golen JA, Manke DR iD

ACS omegaJul 2, 2020License: open accessUnited States26 citationsDOI: 10.1021/acsomega.0c02208

Abstract

The putative active metabolite of aeruginascin, a naturally occurring tryptamine of "magic mushrooms," has been synthesized and structurally characterized. Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT1A, 5-HT2A, and 5-HT2B, though it does not bind at the 5-HT3 receptor, where activity was previously predicted.

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Psilocybin

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