Transformations in the relationship with finitude mediated by psychedelic experiences in people with serious illness: a synthesis of qualitative evidence
Abstract
Context: People living with serious illness frequently experience intense existential suffering related to awareness of finitude. Psychedelic-assisted therapies have been associated with reductions in death anxiety and existential distress, yet the experiential processes underlying transformations in the relationship with finitude remain insufficiently understood. Objectives: To synthesize qualitative evidence on the meanings, experiential processes, and transformations related to finitude reported by people with serious illness in the context of psychedelic use. Methods: A systematic review of qualitative evidence was conducted following JBI guidance and reported in accordance with ENTREQ and PRISMA-2020. Five databases and gray literature were searched without language or date restrictions. Qualitative primary studies involving adults with serious illness who used psychedelics in clinical/therapeutic or non-clinical contexts will included. Data will synthesized using thematic synthesis.
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