Peer-reviewed articleOpen access
Psychedelics for major depression-From controlled research settings into broader clinical use.
Abstract
Psychedelics have shown promising antidepressant effects in recent phase 2 randomized controlled trials, with phase 3 studies underway. While therapeutic outcomes are encouraging, the underlying mechanisms-from receptor-level pharmacology to subjective experience and context-remain only partially understood. We highlight clinical and mechanistic advances and outline priorities for future research.
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