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Peer-reviewed article

Unlocking the biosynthesis of psychedelic-inspired indolethylamines.

Sen AK, Jones JAiD

Trends in biochemical sciencesDec 29, 2023United States2 citationsDOI: 10.1016/j.tibs.2023.12.009

Abstract

A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.

Topics & conditions

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DMT

Keywords

N-methylationPsychedelic IndolethylamineSerotonin Receptor Binding

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