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Peer-reviewed articleOpen access

Psychedelic therapies reconsidered: compounds, clinical indications, and cautious optimism.

Mitchell JMiD, Anderson BT

Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyJul 21, 2023License: open accessUnited States37 citationsDOI: 10.1038/s41386-023-01656-7

Abstract

The clinical investigation of psychedelic medicines has blossomed over the last 5 years. Data from a Phase 3 industry trial and a multicenter Phase 2 industry trial, in addition to multiple early phase investigator-initiated and industry trials, have now been published in peer-reviewed journals. This narrative review summarizes both the recent data and the current clinical trials that are being conducted with various classes of "psyche-manifesting" substances, which may prove beneficial in the treatment of a broad range of conditions. Methodological considerations, unique challenges, and next steps for research are discussed in keeping with the uniquely "experiential" nature of these therapies.

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Psychedelics

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