Peer-reviewed article

The role of BDNF promoter VI in mediating protective effects of prophylactic (R,S)-ketamine.

Chen BK iD, Williams BL iD, Darling A, Bath K iD, Martinowich K iD, Denny CA iD

Neuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyAug 29, 2026United States0 citationsDOI: 10.1038/s41386-026-02536-6

Abstract

Brain-derived neurotrophic factor (BDNF) exon VI promoter is implicated in mediating activity-induced synthesis of hippocampal BDNF. BDNF is implicated in (R,S)-ketamine's antidepressant effects, but its role in (R,S)-ketamine-mediated prophylaxis is unknown. Using BDNF-e6 mice, in which promoter VI-driven BDNF production is disrupted, we tested its necessity for (R,S)-ketamine's prophylactic effects.

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Ketamine

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