Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond.
Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT<sub>2A</sub>R, 5-HT<sub>2B</sub>R and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT<sub>2A</sub>R and 5-HT<sub>2B</sub>R and one compound showed a higher selectivity towards 5-HT<sub>2A</sub>R than psilocin.
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