The influence of psilocybin-assisted therapy on self-referential processing in patients with treatment-resistant depression

Abstract

Psilocybin-assisted therapy is a promising approach for treating treatment-resistant depression (TRD) (Haikazian et al., 2023, Goodwin et al., 2022, Carhart-Harris et al., 2016), but the neural mechanisms underlying psilocybin’s therapeutic effects in depression remain largely unclear. Depression involves increased self-focus and aberrant self-referential processing (Northoff, 2007), which has been linked to altered neural activity in cortical midline structures (Lou et al., 2019). The impact of psilocybin on self-referential processing in TRD has not yet been explored. Here, we want to investigate the influence of psilocybin-assisted therapy on self-referential processing in patients with TRD who took part in the bi-centric, double-blind, randomized controlled EPIsoDE trial (EudraCT:2019-003984-24; NCT04670081).

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