Methodological challenges in psychedelic-assisted therapy research for substance use disorders

Abstract

This systematic scoping review examines how existing reviews address methodological challenges in psychedelic-assisted therapy (PAT) research for substance use disorders (SUD) treatment. The project maps coverage of critical issues including blinding integrity, statistical power, conflicts of interest, and generalizability across review literature. Primary objectives include analyzing the relationship between methodological critique depth and evaluative tone of reviews' conclusions, identifying patterns in quality assessment practices, and examining how methodological limitations influence evidence interpretation. Expected outcomes include comprehensive mapping of methodological reporting gaps and recommendations for improving research and raporting standards as the field transitions toward regulatory approval phases.

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