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Peer-reviewed articleOpen access

Psychedelic- and Substance-Assisted Therapies in Global Mental Health: Bridging Cultures, Evidence, and Access.

Halm SiD

Brain and behaviorFeb 1, 2026License: open accessSwitzerland1 citationsDOI: 10.1002/brb3.71265

Abstract

Psychedelic- and substance-assisted therapies, including MDMA, psilocybin, and ketamine, are gaining attention for conditions such as PTSD and depression, yet their development and implementation remain largely concentrated in high-income settings. This graphical abstract summarizes the central argument of the commentary: while these interventions may hold relevance for global mental health, particularly in conflict-affected and humanitarian contexts, their equitable use is constrained by cultural, ethical, regulatory, and resource-related challenges. Responsible implementation requires culturally grounded, ethically robust, and context-sensitive pathways rather than uncritical expansion.

Topics & conditions

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PsilocybinMDMAKetamineDepressionPTSD

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